TY - JOUR TI - Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes AU - Gelencsér, Zsolt AU - Choudhary, Kumari Sonal AU - Coutinho, Bruna Goncalves AU - Hudaiberdiev, Sanjarbek AU - Galbáts, Borisz AU - Venturi, Vittorio AU - Pongor, Sándor T2 - Sensors AB - Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/. DA - 2012/05// PY - 2012 DO - 10.3390/s120505432 DP - www.mdpi.com VL - 12 IS - 5 SP - 5432 EP - 5444 J2 - Sensors LA - en UR - https://www.mdpi.com/1424-8220/12/5/5432 Y2 - 2020/08/06/16:22:13 KW - N-AHL KW - bacteria KW - proteobacteria KW - quorum sensing KW - topology ER -