NATO Advanced Research Workshop

Structural Biology and Functional Genomics

4-8 May, 1998, ICGEB, Trieste, Italy

Organizers

  • Sándor Pongor (ICGEB, Trieste, Italy)
  • E. Morton Bradbury Los Alamos National Labs, USA

Program

MONDAY, 4 May
08.30COURSE REGISTRATIONFoyer, ICGEB, W Building
09.30WELCOME ADDRESSSeminar Room, ICGEB
S. Pongor (ICGEB, Trieste, Italy)
09.45INTRODUCTIONE. M. Bradbury (Los Alamos National Laboratory, NM, USA)
10.00Genome and Chromosome OrganizationU. K. Laemmli (University of Geneva, Switzerland)
Chromosomal loops and chromatin domains
11.00BREAK
11:30Genome and Chromosome Organization (cont.)T. Cavalier-Smith and M.J. Beaton (University of
British Columbia, Vancouver, Canada)
Genome size evolution in ancient eukaryote/eukaryote chimaeras: implications for the function of nuclear non-coding DNA
12.30Genome and Chromosome Organization (cont.)M. Radman (Institut J. Monod, Paris, France)
Genome organisation and polymorphism as hallmarks of mechanisms for chromosomal maintenance and evolution
13.30LUNCHCafeteria, Ground Floor, Building C
14.30Nucleic Acids Structures and DNA SupercoilingA. Rich (MIT, Boston, MD, USA  041 522 7034  5 8 Riva 2nd)
Alternative DNA conformations and some Functional Properties
15.30Nucleic Acids Structures and DNA Supercoiling (cont.)N. Cozzarelli (University of California Berkeley, CA, USA)
Mechanisms of Chromosome Segregation
16:30Nucleic Acids Structures and DNA Supercoiling (cont.)V. Ivanov (Institute of Molecular Biology, Moscow, Russia)
A-DNA
17.30END OF SESSION/GET-TOGETHER PARTYStaff Common Room, ICGEB,   W Building
18.30BUS TO HOTEL
TUESDAY, 5 May
09.00Nucleic Acids Structures and DNA Supercoiling (cont.)D. Lilley (University of Dundee, UK)
RNA folding and catalytic activity
10.15Nucleic Acids Structures   and DNA Supercoiling (cont.)G. Gupta (Los Alamos National Laboratory, NM, USA)
Repetitive DNA Sequences in the Human Genome
11.30BREAK
12.00Nucleic Acids Structures and DNA SupercoilingCynthia McMurray (Mayo Medical Foundation, Rochester, USA)
Cause and effects of DNA expansion in human disease
13.30LUNCH
14.15Protein Structure and Functional GenomicsT. Terwilliger (Los Alamos National Laboratory, NM, USA)
Exploring Protein Structure Space: A Protein Structure Initiative
15.30Protein Structure and Functional Genomics (cont.)M. Galperin and E. Koonin (National Institute of Health, Bethesda, MD, USA)
Comparison of complete genomes and evolution of protein families
16.45BREAK
17:00Protein Structure and Functional Genomics –> Tue 17:00J. Sussman (Protein Data Bank (PDB), Brookhaven National Laboratory, CN, USA and Weizmann Institute, Rehovot, Israel)
Bridging the Gap Between 3D Structure and the Genome World
18.00BUS TO HOTEL
WEDNESDAY, 6 May
09.00Genome and Chromosome Organization (continuation from Mon., 4 May)S. Oliver (UMIST, Manchester, UK)
The Yeast Genome Project:  Systematic analysis of gene function
10.15DNA Bending and ModellingA. Travers (MRC Laboratory of Molecular Biology, Cambridge, UK)
Chemical determinants of DNA flexibility and their relevance to nucleosome positioning
11.30BREAK
12.00DNA Bending and Modelling (cont.)S. Pongor (ICGEB)
Models of DNA bending
13.30LUNCH
14.15DNA Bending and Modelling (cont.)R. Lavery (Institut de Biologie Physico-Chimique, Paris, France)
Modelling DNA deformation and protein binding
15.30DNA Bending and Modelling (cont.)J. Langowski (DKFZ, Heidelberg, Germany)
Large DNAs and chromatin studied by solution scattering and computer models
16:45BREAK
17.00DNA Bending and Modelling (cont.)V. Zhurkin (National Institutes of Health, Bethesda, MD, USA)
DNA Bending in Tetrameric Complex with Tumor Suppressor Protein p53: Computer Modeling and Comparison with Experiment
18.00BUS TO HOTEL
THURSDAY, 7 May
09.00Nucleosome and Chromatin StructuresE. M. Bradbury (Los Alamos National Laboratory, NM, USA)
Packaging of the Genome: Nucleosome and Chromatin Structures
10:15Nucleosome and Chromatin StructuresM. Giacca (ICGEB, Trieste)
Origins of DNA replication in mammalian chromosomes
11.30BREAK
12:00Nucleosome and Chromatin Structures (cont.)V. Giancotti (U. Trieste)
Structure and function of HMGI chromosomal proteins
13.30LUNCH
14.30New Approaches to Functional GenomicsD. Bensimmon (Ecole Normale Superieure, Paris, France)
Twisting and stretching single DNA molecules: structure and function
15.45New Approaches to Functional Genomics (cont.)Chris  Aston and David Schwartz (New York University, NY, USA)
Whole genome analysis by optical mapping
16.45BREAK
17.00New Approaches to Functional Genomics (cont.)A. Bradbury (International School for Advanced Studies, Trieste, Italy)
Phage display and potential applications in the human genome project
18.00BUS TO HOTEL
FRIDAY, 8 May
9:00VISIT TO THE ELETTRA SYCHROTRONEA. Savoia and F. Zanin, (Elettra Synchrotron, Trieste)
The beamlines of Elettra and their applications to structural biology
11:00VISIT TO THE ICGEB LABORATORIESFoyer, ICGEB, W Building
CLOSING OF THE WORKSHOP
13.30LUNCH
14.30BUS TO HOTEL

Invited Speakers

ASTON, Christopher W.W. M. Keck Laboratory for Biomolecular Imaging, Department of Chemistry, New York University, 31 Washington Place, New York, NY 10003, USA. Telephone: +1-212-9981371; Fax: +1-212- 9954681; E-mail:  
BENSIMON, DavidDepartment of Complex Systems, Weizmann Institute, 76100 Rehovot, ISRAEL. Telephone: +972-8-9342061/2671/3263; Fax: +972-8-9344109; E-mail: ,  
BRADBURY, AndrewSISSA Laboratory, ICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-398995; Fax: +39-40-398991; E-mail:  
BRADBURY, E. MortonLife Sciences Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Telephone: +1-505-6672690; Fax: +1-505-6672891; E-mail: ,  
CAVALIER-SMITH, TomDepartment of Botany, University of British Columbia, Vancouver, CANADA.  Fax: +1-604-8226089; E-mail:  
COZZARELLI, Nicholas R.Department of Molecular and Cell Biology, University of California, Berkeley, 401 Barker Hall #3204, Berkeley, CA 94720-3204, USA. Telephone: +1-510-6425266; Fax: +1-510-6431079; E-mail:  
GALPERIN, MichaelNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38A, Bethesda, MD 20894, USA. Telephone: +1-301-4962477 ext294; Fax: +1-301-4809241; E-mail: ,  
GIACCA, MauroICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757324; Fax: +39-40-226555; E-mail:  
GIANCOTTI, VincenzoDipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universitŕ di Trieste, Via L. Giorgeri 1, 34100 Trieste, ITALY. Telephone: +39-40-6763676; Fax: +39-40-6763694; E-mail:  
GUPTA, GoutamTheoretical Biology and Biophysics, T-10, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Telephone: +1-505-6652587; Fax: +1-505-6653493, 6673493; E-mail:  
IVANOV, Valerii I.V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str., 117984 Moscow, RUSSIA. Telephone: +7-095-1351255; Fax: +7-095-1351405; E-mail:  
LAEMMLI, Ulrich K.Department of Molecular Biology, University of Geneva, 30, quai Ernest Ansermet, 1211 Geneva 4, SWITZERLAND. Telephone: +41-22-7026122; Fax: +41-22-3290696; E-mail:  
LANGOWSKI, JörgDivision Biophysics of Macromolecules, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, GERMANY. Telephone: +49-6221-423390; Fax: +49-6221-423391; E-mail:  
LAVERY, RichardLaboratoire de Biochimie Theorique/CNRS UPR 9080, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005 Paris, FRANCE. Telephone: +33-1-43252609; Fax: +33-1-43295645; E-mail:  
LILLEY, David M. J.Department of Biochemistry, University of Dundee, Dundee DD1 4HN, UK. Telephone: +44-1382-344243, 070-500-84350 (mobile phone); Fax: +44-1382-201063; E-mail:  
MCMURRARY, Cynthia T.Department of Pharmacology, Department of Biochemistry and Molecular Biology, Mayo Medical Foundation, Rochester, MN 55905, USA. Telephone: +1-507-2841597; Fax: +1-507-2849111; E-mail:  
OLIVER, SteveDepartment of Biomolecular Sciences, UMIST, P.O. Box 88, Sackville St., Manchester M60 1QD, UK. Telephone: +44-161-2004222, 2004203; Fax: +44-161-2360406; E-mail:  
PONGOR, SŕndorICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757300; Fax: +39-40-226555; E-mail:  
RADMAN, MiroslavLaboratory of Mutagenesis, Institut Jacques Monod, Université de Paris, Tour 43, 2 Place Jussieu, 75251 Paris Cedex 05, FRANCE. Telephone: +33-1-44274731; Fax: +33-1-44275716, 44277870; E-mail:  
RICH, AlexanderDepartment of Biology, MIT, Room 68-233, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. Telephone: +1-617-2534715; Fax: +1-617-2538699; E-mail:  
SUSSMAN, Joel L.Protein Data Bank, Biology Department, Bldg. 463, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Telephone: +1-516-3446355; Fax: +1-516-3442176; E-mail: of Structural Biology, Weizmann Institute of Science, Rehovot 76100, ISRAEL. Telephone: +972-8-9342638; Fax: +972-8-9344159; E-mail:  
TERWILLIGER, TomLife Sciences Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Telephone: +1-505-6670072; Fax: +1-505-6653024; E-mail:  
TRAVERS, Andrew A.MRC Laboratory of Molecular Biology, Hills Road, Cambrige CB2 2QH, UK. Telephone: +44-223-248011; Fax: +44-223-213556; E-mail:  
ZHURKIN, VictorLaboratory of Experimental and Computational Biology, National Cancer Institute, NIH, Bg. 12B, Rm. B116, MSC 5677, 12 South Drive, Bethesda, MD 20892-5677, USA. Telephone: +1-301-4968913; Fax: +1-301-4024724; E-mail:  

Other Participants

ARANDA-ANZALDO, ArmandoLaboratorio de Biología Molecular, Facultad de Medicina, UAEM, Apdo. Postal 428, C.P. 50000, Toluca, Edo. Méx, MEXICO. Telephone: +52-72-173552; Fax: +52-72-174564, 174142; E-mail:
ATALAN, EkremBiology Department, Science and Art Faculty, Yuzuncu Yil University, Van, TURKEY. Telephone: +90-432-2251083 ext 1129; Fax: +90-432-2251114 
ATHANASSIADIS, AlekosICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757354; Fax: +39-40-226555; E-mail:  
BENETTI, RobertaCIB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-398992; Fax: +39-40-398990; E-mail:  
BENVENUTI, FedericaICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757310; Fax: +39-40-226555; E-mail:  
BOSUTTI, AlessandraLaboratorio di Nutrizione Clinica, Istituto di Clinica Medica, Ospedale di Cattinara, Strada di Fiume, 34100 Trieste, ITALY. Telephone: +39-40-3994597; Fax: +39-40-3994593 
BUCHTELOVA, EvaInstitute of Organic Chemistry and Biochemistry, Flemingovo nam. 2, 16610 Praha 6, CZECH REPUBLIC. Telephone: +420-2-20183292; E-mail:  
DAPAS, BarbaraDepartment of Biomedical Sciences and Technologies, University of Udine, Via Gervasutta 45, 33100 Udine, ITALY. Telephone: +39-432-523121; Fax: +39-432-600828 
DE SANCTIS, VeronicaCentro Acidi Nucleici, Ex-Istituto di Fisiologia, Universitŕ degli Studi di Roma, Piazzale A. Moro 5, 00185 Roma, ITALY. Telephone: +39-6-49912897; Fax: +39-6-49912500; E-mail:  
DEGANUTO, MartaICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757325; Fax: +39-40-226555; E-mail:  
DEL TERRA, ElisaDepartment of Biological Sciences and Technologies, University of Udine, Via Gervasutta 48, 33100 Udine, ITALY. Telephone: +39-432-729348, 523121; Fax: +39-432-600828 
FABBRETTI, ElsaICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757310; Fax: +39-40-226555; E-mail:  
GAMEL, KatiaSISSA Laboratory, c/o ICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757355; Fax: +39-40-398991; E-mail:  
GOSTISSA, MonicaCIB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-398991; Fax: +39-40-398990; E-mail:  
GUBENSEK, FrancDepartment of Biochemistry, J. Stefan Institute, Jamova 39, 1000 Ljubljana, SLOVENIA. Telephone: +386-61-1773250; Fax: +386-61-273594; E-mail:  
GUFFANTI, AlessandroTelethon Institute of Genetics and Medicine, c/o DIBIT, Via Olgettina 58, 20132 Milano, ITALY. Telephone: +39-2-21560212; Fax: +39-2-21560220; E-mail:  
HASEK, JINDRICHInstitute of Macromolecular Chemistry, 16206 Praha 6, CZECH REPUBLIC. Telephone: +42-2-360341 EXT 205; E-mail:  
KORDIS, DusanDepartment of Biochemistry and Molecular Biology, J. Stefan Institute, Jamova 39, 1000 Ljubljana, SLOVENIA. Telephone: +386-61-1773611; Fax: +386-61-273594; E-mail:  
LIBERATI, ChiaraDipartimento di Genetica e di Biologia dei Microrganismi, Universitŕ degli Studi di Milano, Via Celoria 26, 20133 Milano, ITALY. Telephone: +39-2-26605224; Fax: +39-2-2664551; E-mail:  
MANTOVANI, FiammaICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757331; Fax: +39-40-226555; E-mail:  
MARRO, MartinICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757312; Fax: +39-40-226555; E-mail:  
MENDOZA MALDONADO, RamiroICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757325; Fax: +39-40-226555; E-mail:  
MORASSUTTI, CarlaDepartment of Biomedical Sciences and Technologies, University of Udine, Via Gervasutta 48, 33100 Udine, ITALY. Telephone: +39-432-523121; Fax: +39-432-600828; E-mail:  
NIKSIC, MartinaICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757312; Fax: +39-40-226555; E-mail:  
ODREMAN MACCHIOLI, Federico E.ICGEB, AREA Science Park, Padriciano 99, 34012 Trieste, ITALY. Telephone: +39-40-3757316; Fax: +39-40-226555; E-mail:
PARONI, GabrielaDepartment of Biomedical Sciences and Technologies, University of Udine, Via Gervasutta 45, 33100 Udine, ITALY. Telephone: +39-432-917165, 523121; Fax: +39-432-600828

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